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Scientific References

General
Orthobioloogics
Wounds & Cosmetics

General

  1. Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell. 2011 Jul 8;9(1):11-5. doi: 10.1016/j.stem.2011.06.008. PMID: 21726829; PMCID: PMC3144500.
  2. Murphy MB, Moncivais K, Caplan AI. MESENCHYMAL STEM CELLS: ENVIRONMENTALLY RESPONSIVE THERAPEUTICS FOR REGENERATIVE MEDICINE. Exp Mol Med. 2013 Nov 15;45(11): e54. doi: 10.1038/emm.2013.94. PMID: 24232253; PMCID: PMC3849579., https://pubmed.ncbi.nlm.nih.gov/24232253/
  3. Dr. Arnold Caplin PhD, MESENCHYMAL STEM CELLS AND REGENERATIVE MEDICINE, https://www.youtube.com/watch?v=qa3mMNH8Jfw
  4. Dr. Steven R. Bauer, Ph.D., the chief of the FDA’s Cellular and Tissues Therapy Branch, Division of Cellular and Gene Therapies, in the Office of Tissues and Advanced Therapies at FDA’s Center for Biologics Evaluation and Research in PREDICTING STEM CELL ACTIVITY TO ENSURE SAFE AND EFFECTIVE THERAPIES, https://collaboration.fda.gov/p20bercyc7m/?launcher=false&fcsContent=true&pbMode=normal
  5. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine, https://www.nature.com/articles/emm201394#Sec
  6. Why are MSCs therapeutic? New data: New Insight, https://www.researchgate.net/publication/23487858_Why_are_MSCs_therapeutic_New_data_New_Insight
  7. Are Stem Cells Ready for Prime Time? A Look at FDA Research Advances in Regenerative Medicine, https://www.fda.gov/science-research/about-science-research-fda/are-stem-cells-ready-prime-time-look-fda-research-advances-regenerative-medicine
  8. Han S, Sun HM, Hwang KC, Kim SW. ADIPOSE-DERIVED STROMAL VASCULAR FRACTION CELLS: UPDATE ON CLINICAL UTILITY AND EFFICACY. Crit Rev Eukaryot Gene Expr. 2015;25(2):145-52. doi: 10.1615/critreveukaryotgeneexpr.2015013057. PMID: 26080608., https://pubmed.ncbi.nlm.nih.gov/26080608/
  9. Mesenchymal stem cell perspective: cell biology to clinical progress, https://www.nature.com/articles/s41536-019-0083-6#Tab1
  10. da Silva Meirelles, Lindolfo, Arnold I. Caplan, and Nance Beyer Nardi. “IN SEARCH OF THE IN VIVO IDENTITY OF MESENCHYMAL STEM CELLS.” Stem cells 26.9 (2008): 2287-2299, https://pubmed.ncbi.nlm.nih.gov/18566331/
  11. da Silva Meirelles, Lindolfo, et al. “Mechanisms involved in the therapeutic properties of mesenchymal stem cells.” Cytokine & growth factor reviews 20.5-6 (2009): 419-427., https://pubmed.ncbi.nlm.nih.gov/19926330/
  12. Adipose-Derived Mesenchymal Stromal/Stem Cells: Tissue Localization, Characterization, and Heterogeneity, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345279/
  13. Mesenchymal stem cell perspective: cell biology to clinical progress, https://www.sciencedirect.com/topics/medicine-and-dentistry/adipose-derived-stem-cell
  14. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure, https://pubmed.ncbi.nlm.nih.gov/16698690/
  15. Crisan, Mihaela, et al. “A PERIVASCULAR ORIGIN FOR MESENCHYMAL STEM CELLS IN MULTIPLE HUMAN ORGANS.” Cell stem cell 3.3 (2008): 301-313.
  16. Reckhenrich AK, Kirsch BM, Wahl EA, Schenck TL, Rezaeian F, Harder Y, Foehr P, Machens HG, Egaña JT. Surgical sutures filled with adipose-derived stem cells promote wound healing. PLoS One. 2014 Mar 13;9(3):e91169. doi: 10.1371/journal.pone.0091169. PMID: 24625821; PMCID: PMC3953386., https://pubmed.ncbi.nlm.nih.gov/24625821/
  17. Bianchi, Francesca, et al. “A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte- like elements by mild mechanical forces from human lipoaspirates.” Cell transplantation 22.11 (2013): 2063-2077.
  18. Adipose-Derived Mesenchymal Stromal/Stem Cells: Tissue Localization, Characterization, and Heterogeneity, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345279/#B22
  19. ADSCs enhance motor and sensory functional recovery in injured peroneal nerves compared with positive and negative controls., https://www.sciencedirect.com/topics/medicine-and-dentistry/adipose-derived-stem-cell
  20. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human ADIPOSE TISSUE IS A SOURCE OF MULTIPOTENT STEM CELLS. Mol Biol Cell. 2002 Dec;13(12):4279-95. doi: 10.1091/mbc.e02- 02-0105. PMID: 12475952; PMCID: PMC138633, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138633/
  21. Wang Q, Zhou L, Guo Y, Liu G, Cheng J, Yu H. Differentiation of human adipose-derived stem cells into neuron-like cells by Radix Angelicae Sinensis. Neural Regen Res. 2013 Dec 15;8(35):3353-8. doi: 10.3969/j.issn.1673-5374.2013.35.010. PMID: 25206657; PMCID: PMC4145944, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145944/

Orthobiologics

  1. Caplan AI. All MSCs are pericytes? Cell Stem Cell 2008; 3:229–230., https://www.sciencedirect.com/science/article/pii/S1934590908004062
  2. Russo A, Screpis D, Di Donato SL et al (2017) Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis. J Exp Orthop 4:33, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300453/
  3. Ceserani V, Ferri A, Berenzi A, et al. Angiogenic and anti‐inflammatory properties of micro‐fragmented fat tissue and its derived mesenchymal stromal cells. Vasc Cell 2016; 8:3. [PMC free article] [PubMed] [Google Scholar]
  4. Vezzani B, Shaw I, Lesme H, et al. Higher pericyte content and secretory activity of micro fragmented human adipose tissue compared to enzymatically derived stromal vascular fraction. Stem Cells Translational Medicine 2018; 7:876–886. [PMC free article] [PubMed] [Google Scholar]
  5. Russo A, Screpis D, Di Donato SL et al (2017) Autologous and micro-fragmented adipose tissue for the treatment of diffuse degen- erative knee osteoarthritis. J Exp Orthop 4:33
  6. Piovan G, Zorzi C. Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3-year follow-up. J Exp Orthop. 2018 Dec 19;5(1):52. doi: 10.1186/s40634-018-0169-x. PMID: 30569417; PMCID: PMC6300453., https://pubmed.ncbi.nlm.nih.gov/30569417/
  7. Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3-year follow-up, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300453/
  8. Freitag J, Wickham J, Shah K, Tenen A. REAL-WORLD EVIDENCE OF MESENCHYMAL STEM CELL THERAPY IN KNEE OSTEOARTHRITIS: A LARGE PROSPECTIVE TWO-YEAR CASE SERIES. Regen Med. 2022 Jun;17(6):355-373. doi: 10.2217/rme-2022- 0002. Epub 2022 Apr 12. PMID: 35411799., https://pubmed.ncbi.nlm.nih.gov/35411799/
  9. Freitag J, Bates D, Wickham J, Shah K, Huguenin L, Tenen A, Paterson K, Boyd R. ADIPOSE-DERIVED MESENCHYMAL STEM CELL THERAPY IN THE TREATMENT OF KNEE OSTEOARTHRITIS: A RANDOMIZED CONTROLLED TRIAL. Regen Med. 2019 Mar;14(3):213-230. doi: 10.2217/rme-2018-0161. Epub 2019 Feb 14. PMID: 30762487., https://pubmed.ncbi.nlm.nih.gov/30762487/
  10. Lee WS, Kim HJ, Kim KI, Kim GB, Jin W. INTRA-ARTICULAR INJECTION OF AUTOLOGOUS ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS FOR THE TREATMENT OF KNEE OSTEOARTHRITIS: A PHASE IIB, RANDOMIZED, PLACEBO- CONTROLLED CLINICAL TRIAL. Stem Cells Transl Med. 2019 Jun;8(6):504-511. doi: 10.1002/sctm.18-0122. Epub 2019 Mar 5. PMID: 30835956; PMCID: PMC6525553., https://pubmed.ncbi.nlm.nih.gov/30835956/
  11. Vezzani B, Shaw I, Lesme H, et al. Higher pericyte content and secretory activity of micro fragmented human adipose tissue compared to enzymatically derived stromal vascular fraction. Stem Cells Translational Medicine 2018; 7:876–886. [PMC free article] [PubMed] [Google Scholar
  12. Russo A, Screpis D, Di Donato SL et al (2017) Autologous and micro-fragmented adipose tissue for the treatment of diffuse degen- erative knee osteoarthritis. J Exp Orthop 4:33
  13. Piovan G, Zorzi C. Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3-year follow-up. J Exp Orthop. 2018 Dec 19;5(1):52. doi: 10.1186/s40634-018-0169-x. PMID: 30569417; PMCID: PMC6300453., https://pubmed.ncbi.nlm.nih.gov/30569417/
  14. Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3-year follow-up, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300453/
  15. Freitag J, Wickham J, Shah K, Tenen A. REAL-WORLD EVIDENCE OF MESENCHYMAL STEM CELL THERAPY IN KNEE OSTEOARTHRITIS: A LARGE PROSPECTIVE TWO-YEAR CASE SERIES. Regen Med. 2022 Jun;17(6):355-373. doi: 10.2217/rme-2022- 0002. Epub 2022 Apr 12. PMID: 35411799., https://pubmed.ncbi.nlm.nih.gov/35411799/
  16. Freitag J, Bates D, Wickham J, Shah K, Huguenin L, Tenen A, Paterson K, Boyd R. ADIPOSE-DERIVED MESENCHYMAL STEM CELL THERAPY IN THE TREATMENT OF KNEE OSTEOARTHRITIS: A RANDOMIZED CONTROLLED TRIAL. Regen Med. 2019 Mar;14(3):213-230. doi: 10.2217/rme-2018-0161. Epub 2019 Feb 14. PMID: 30762487., https://pubmed.ncbi.nlm.nih.gov/30762487/
  17. Lee WS, Kim HJ, Kim KI, Kim GB, Jin W. INTRA-ARTICULAR INJECTION OF AUTOLOGOUS ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS FOR THE TREATMENT OF KNEE OSTEOARTHRITIS: A PHASE IIB, RANDOMIZED, PLACEBO- CONTROLLED CLINICAL TRIAL. Stem Cells Transl Med. 2019 Jun;8(6):504-511. doi: 10.1002/sctm.18-0122. Epub 2019 Mar 5. PMID: 30835956; PMCID: PMC6525553., https://pubmed.ncbi.nlm.nih.gov/30835956/
  18. Hong Z, Chen J, Zhang S, Zhao C, Bi M, Chen X, Bi Q. INTRA-ARTICULAR INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STROMAL VASCULAR FRACTIONS FOR KNEE OSTEOARTHRITIS: A DOUBLE-BLIND RANDOMIZED SELF-CONTROLLED TRIAL. Int Orthop. 2019 May;43(5):1123-1134. doi: 10.1007/s00264-018-4099-0. Epub 2018 Aug 14. PMID: 30109404., https://pubmed.ncbi.nlm.nih.gov/30109404/
  19. Anil U, Markus DH, Hurley ET, Manjunath AK, Alaia MJ, Campbell KA, Jazrawi LM, Strauss EJ. THE EFFICACY OF INTRA- ARTICULAR INJECTIONS IN THE TREATMENT OF KNEE OSTEOARTHRITIS: A NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Knee. 2021 Oct; 32:173-182. doi: 10.1016/j.knee.2021.08.008. Epub 2021 Sep 6. PMID: 34500430., https://pubmed.ncbi.nlm.nih.gov/34500430/
  20. Aletto C, Giordano L, Quaranta M, Zara A, Notarfrancesco D, Maffulli N. SHORT-TERM RESULTS OF INTRA-ARTICULAR INJECTIONS OF STROMAL VASCULAR FRACTION FOR EARLY KNEE OSTEOARTHRITIS. J Orthop Surg Res. 2022 Jun 11;17(1):310. doi: 10.1186/s13018-022-03196-0. PMID: 35690837; PMCID: PMC9188722., https://pubmed.ncbi.nlm.nih.gov/35690837/
  21. The efficacy of intra-articular injections in the treatment of knee osteoarthritis: A network meta-analysis of randomized controlled trials, https://en.x-mol.com/paper/article/1435380959792656384
  22. Qu, H., Sun, S. EFFICACY OF MESENCHYMAL STROMAL CELLS FOR THE TREATMENT OF KNEE OSTEOARTHRITIS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. J Orthop Surg Res 16, 11 (2021). https://doi.org/10.1186/s13018-020-02128-0, https://josr-online.biomedcentral.com/articles/10.1186/s13018-020-02128-0
  23. Lipogems Prospective Study, https://clinicaltrials.gov/ct2/show/NCT03922490
  24. Mesenchymal stem cells in knee osteoarthritis treatment: A systematic review and meta-analysis, https://www.sciencedirect.com/science/article/pii/S2214031X20300450
  25. Treatment of Knee Osteoarthritis with Autologous Mesenchymal Stem Cells: A Pilot Study, https://journals.lww.com/transplantjournal/fulltext/2013/06270/Treatment_of_Knee_Osteoarthritis_With_Autologous.17.aspx

Wound Care & Cosmetics

  1. Regenerative Scar-Free Skin Wound Healing, https://pubmed.ncbi.nlm.nih.gov/30938269/
  2. The Role of MSC in Wound Healing, Scarring and Regeneration, Cells. 2021 Jul; 10(7): 1729, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305394/
  3. Regenerative Scar-Free Skin Wound Healing, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686695/
  4. Adipose Tissue-Derived Mesenchymal Stem Cells Have a Heterogenic Cytokine Secretion Profile, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470019/
  5. Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats, Diabetes Research and Clinical PracticeVolume 93, Issue 2, August 2011, Pages 228-234, https://www.sciencedirect.com/science/article/abs/pii/S0168822711002233
  6. Three-dimensional cultivation of human adipose-derived stem cells with human decellularized adipose tissue matrix scaffold promotes diabetic wound healing, https://www.sciencedirect.com/science/article/abs/pii/S0927775722002321
  7. The Role of MSC in Wound Healing, Scarring and Regeneration, Cells. 2021 Jul; 10(7): 1729. Published online 2021 Jul 8. doi: 10.3390/cells10071729
  8. Human mesenchymal stem cells are resistant to UV-B irradiation, https://freidok.uni-freiburg.de/data/151829
  9. Caplan A: 2013: Mesenchymal stem cells environmentally responsive therapeutics for regenerative medicine. Experimental & Molecular medicine. 45(11): e54.
  10. Kim, W. S. et al. Evidence supporting antioxidant action of adipose-derived stem cells: protection of human dermal fibroblasts from oxidative stress. J Dermatol Sci 49, 133-142, https://doi.org/10.1016/j.jdermsci.2007.08.004
  11. Kim, W. S., Park, B. S., Park, S. H., Kim, H. K. & Sung, J. H. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J. Dermatol. Sci. 53, 96-102, https://doi.org/10.1016/j.jdermsci.2008.08.007
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